Mansoor Amiji
University Distinguished Professor,
Pharmaceutical Sciences
University Distinguished Professor,
Chemical Engineering
Affiliated Faculty,
Bioengineering
Contact
- m.amiji@northeastern.edu
- 360 Huntington Avenue
Boston, MA 02115
Office
- 140 The Fenway, Room 165
- 617.373.3137
Research Focus
Polymeric biomaterials, drug delivery systems, nanomedical technologies
Education
- BS, Pharmacy (magna cum laude), Northeastern University
- PhD, Pharmaceutics, Purdue University
Honors & Awards
- T. Nagai Award, Controlled Release Society
- Fellow, America Association of Pharmaceutical Scientists (AAPS)
- Fellow, American Institute for Medical and Biological Engineers (AIMBE)
- Fellow, Controlled Release Society
- Charivate Analytics Highly Cited Author (top 1%)
- Distinguished Alumni Award, Purdue University College of Pharmacy
Professional Affiliations
- American Association of Pharmaceutical Scientists, Fellow
- Controlled Release Society, Fellow
Research Overview
Polymeric biomaterials, drug delivery systems, nanomedical technologies
Translational Therapeutic Delivery Laboratory
Success in pharmaceutical and biotechnology product development requires safe and efficient delivery of the therapeutic agent to its target site, which may be quite remote from the administration site. Currently, there are two main challenges in drug delivery: (1) hard-to-deliver molecules and (2) hard-to-reach target sites in the body.
At Northeastern University, we explore customized, innovative solutions to deliver therapeutic and vaccine payloads to their target sites (e.g., brain). Challenging biological molecules such as proteins, peptides, and nucleic acids require efficient delivery modalities to enable their therapeutic functions.
Our approach focuses on multidisciplinary expertise in science and engineering and active collaborations with medical professionals and industrial scientists toward successful product development that can benefit patients.
Selected Research Projects
- Combination Strategy for the Treatment of Advanced Pancreatic Cancer
- – Principal Investigator, National Institutes of Health
- Development and Validation of a Novel Cas13a and Nanoparticle Guide-RNA Delivery System that Allows Precise Ablation of Host Macrophage Populations in a Humanized Mouse Model
- – Principal Investigator, Jackson Laboratories on a National Institutes of Health
- Direct CNS Delivery System for BDNF AntagoNATs using Heterotopic Mucosal Grafting for the Treatment of Parkinson’s Disease
- – Principal Investigator, National Institutes of Health
Department Research Areas
Selected Publications
- Bitounis, D., Amiji, M.M. Lipid nanoparticles target haematopoietic stem cells. Nat. Nanotechnol. (2024). https://doi.org/10.1038/s41565-024-01682-6
- J. Bae, N. Parayath, W. Ma, M. Amiji, N. Munshi, K. Anderson, Bcma Peptide Engineered Nanoparticles Enhance Induction and Function of Antigen Specific Cd8+ Cytotoxic T Lymphocytes Against Multiple Myeloma, Nature – Leukemia, 34, 2020, 210–223
- N.N. Parayath, S. Padmakumar, M. Amiji, Extracellular Vesicle-Mediated Nucleic Acid Transfer and Reprogramming in the Tumor Microenvironment, Cancer Letters, 482(10), 2020, 33-43
- G. Ahmad, G. Mackenzie, J. Egan, M. Amiji, Dha-Sbt-1214 Taxoid Nanoemulsion and Anti-Pd-L1 Antibody Combination Therapy Enhances Antitumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma Model, Molecular Cancer Therapeutics, 18(11), 2019, 961-1972
- D. Chen, N. Parayath, S. Ganesh, W. Wang, M. Amiji, Role of Apolipoprotein-and Vitronectin-Enriched Protein Corona on Lipid Nanoparticles for in Vivo Targeted Delivery and Transfection of Oligonucleotides in Murine Tumor Models, Nanoscale, 11, 2019, 18806–18824
Sep 11, 2024
Pioneering Innovative Treatments for GI Diseases
Bouvé/ChE University Distinguished Professor Mansoor Amiji is developing innovative oral nucleic acid delivery systems to revolutionize treatment for gastrointestinal (GI) diseases that aim to deliver genetic medicines directly to the affected areas within the GI tract.
Aug 22, 2024
Nasal Epinephrine Spray Alternative to EpiPen
Bouvé/ChE University Distinguished Professor Mansoor Amiji says a new epinephrine nasal spray recently approved by the FDA is a smaller and less costly device than the EpiPen and doesn’t involve an injection, which could appeal to many people.
Aug 20, 2024
Using Lipid Nanoparticles To Target Blood Stem Cells
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on “Lipid Nanoparticles Target Haematopoietic Stem Cells” was published in Nature Nanotechnology.
Jun 25, 2024
Will the New COVID FLiRT Variant Lead to a Summer Surge? Watch for These Symptoms, Experts Say
Bouvé/ChE University Distinguished Professor Mansoor Amiji was featured in the Medical Xpress article “Will the New COVID FLiRT Variant Lead to a Summer Surge? Watch for These Symptoms, Experts Say.”
Jun 13, 2024
Combo COVID-19-Flu Shot Could Have Broad Appeal
Bouvé/ChE University Distinguished Professor Mansoor Amiji says the convenience of a combined mRNA COVID-19 and flu shot, which successfully completed a late-stage trial at Moderna, could drive up the percentage of people vaccinated against the coronavirus.
Jun 10, 2024
New Approaches for Blood Disease Treatments
Bouvé/ChE University Distinguished Professor Mansoor Amiji’s research on “Lipid Nanoparticles Target Haematopoietic Stem Cells” was published in Nature Nanotechnology.
May 02, 2024
AstraZeneca Admits Vaccine Can Cause Rare Blood-Clotting Condition
Bouvé/ChE University Distinguished Professor Mansoor Amiji gives insight into the risk of getting thrombosis with thrombocytopenia syndrome, or TTS, from the AstraZeneca vaccine for COVID-19.
Mar 25, 2024
Three Faculty Selected as AIMBE Fellows
Bouvé/ChE University Distinguished Professor Mansoor Amiji, ChE/BioE Associate Professor Eno Ebong, and ECE/Khoury Professor Yun Raymond Fu were selected as Class of 2024 Fellows for the American Institute for Medical and Biological Engineering.
Feb 27, 2024
Avoiding Safety Risks for mRNA Therapeutics
Bouvé/ChE University Distinguished Professor Mansoor Amiji co-authored a paper in Nature Reviews Drug Discovery outlining several strategies to check for toxicity at the preclinical level of mRNA therapeutics to ensure patient safety.
Jan 17, 2024
New Cancer Vaccines Could Provide Beneficial Alternative Therapy
Bouvé/ChE University Distinguished Professor Mansoor Amiji sees the promise of new cancer vaccines amid encouraging results from treatment studies.